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In the sleep clinic sample, patients with severe OSA had higher baseline LOX than healthy controls and serum LOX decreased in patients with OSA on continuous positive airway pressure (CPAP) but not in untreated patients suggesting the fact that the hypoxic stress of obstructive sleep apnoea may increase circulating lysyl oxidase (LOX) levels, so LOX may serve as a biomarker of liver fibrosis in patients with severe obesity and non- alcoholic fatty liver disease [37]